Andrean was founded in 1959, and named for St. Andrew, the patron saint of the first bishop of the diocese of the Roman Catholic Diocese of Gary, Andrew Grutka. Through most of its history, Andrean has been staffed in part by members of the Basilian Fathers and the Sisters of Saints Cyril and Methodius. The school colors are red and gold in honor of the martyrdom and subsequent glory of St. Andrew. The school motto is "Magister Meus Christus," or "Christ is My Teacher."
Andrean is committed to the education of the whole person. While the emphasis is placed on academics, students deepen their faith through retreats, liturgical celebrations, and service projects while developing their talents and interests through a broad spectrum of extracurricular activities. The school also has extensive Advanced Placement, Honors, Dual Credit Course Programs, and Internship Programs.